B.Pharmacy 6th Semester Biopharmaceutics and Pharmacokinetics Notes & Important Question Answer
B.Pharma VIth Semester Biopharmaceutics and Pharmacokinetics Important Topics With All The Important Question And Answer Are Publish Here Download the Pdf and Give boost To Your Preparation. Stay Connected with us for your future examination all the important content will publish here . Your Full Pharmacy Syllabus will Be published here.
Biopharmaceutics and Pharmacokinetics - Unit 1
Introduction to Biopharmaceutics:
- Absorption; Mechanisms of drug absorption through GIT, factors influencing drug absorption through GIT, absorption of drug from non per-oral extra-vascular routes.
- Distribution Tissue permeability of drugs, binding of drugs, apparent, volume of drug distribution, plasma and tissue protein binding of drugs, factors affecting protein-drug binding. Kinetics of protein binding, Clinical significance of protein binding of drugs.
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Biopharmaceutics and Pharmacokinetics - Unit 2
- Elimination: Drug metabolism and basic understanding metabolic pathways renal excretion of drugs, factors affecting renal excretion of drugs, renal clearance, Non renal routes of drug excretion of drugs.
- Bioavailability and Bioequivalence: Definition and Objectives of bioavailability, absolute and relative bioavailability, measurement of bioavailability, in-vitro drug dissolution models, in-vitro-in-vivo correlations, bioequivalence studies, methods to enhance the dissolution rates and bioavailability of poorly soluble drugs.
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Biopharmaceutics and Pharmacokinetics - Unit 3
- Pharmacokinetics: Definition and introduction to Pharmacokinetics, Compartment models, Non compartment models, physiological models, One compartment open model. Intravenous Injection (Bolus), Intravenous infusion and Extra vascular administrations. Pharmacokinetics parameters – KE, t1/2, Vd, AUC, Ka, Clt and CLR– definitions, methods of eliminations, understanding of their significance and application.
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Biopharmaceutics and Pharmacokinetics - Unit 4
- Multicompartment models: Two compartment open model. IV bolus Kinetics of multiple dosing, steady state drug levels, calculation of loading and maintenance doses and their significance in clinical settings.
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Biopharmaceutics and Pharmacokinetics - Unit 5
Nonlinear Pharmacokinetics: Introduction, Factors causing Non-linearity. Michaelis-Menten method of estimating parameters, Explanation with example of drugs.
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B.pharma 6th Sem Biopharmaceutics and Pharmacokinetics Unit 1 To 5 Important Topics PDF:- Click Here
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B Pharmacy 6th Semester Notes
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