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| B.Pharmacy 4th Semester Medicinal Chemistry 1 All Units Notes |
Medicinal Chemistry 1- Unit 1
Introduction to Medicinal Chemistry
- History and development of medicinal chemistry
- Physicochemical properties in relation to biological action
- Ionization, Solubility, Partition Coefficient, Hydrogen bonding, Protein binding, Chelation, Bioisosterism, Optical and Geometrical isomerism.
- Drug metabolism
- Drug metabolism principles - Phase I and Phase II.
- Factors affecting drug metabolism including stereo chemical aspects.
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Medicinal Chemistry 1- Unit 2
Drugs acting on Autonomic Nervous System
- Adrenergic Neurotransmitters:
- Biosynthesis and metabolism of catecholamines.
- Adrenergic receptors (Alpha & Beta) and their distribution.
- Sympathomimetic agents: SAR of Sympathomimetic agents.
- Direct acting: Norepinephrine, Epinephrine, Phenylephrine*, Dopamine.
- Methyl dopa*, Clonidine, Dobutamine, Isoprenaline*, Terbutaline, Salbutamol*, Bitolterol, Albuterol, Isoxsuprine and Xylometazoline.
- Indirect acting agents: Hydroxyamphetamine, Tyramine, Amphetamine, Methamphetamine.
- Agents with mixed mechanism: Ephedrine, Mephentermine.
- Adrenergic Antagonists:
- Alpha adrenergic blockers: Tolazoline*, Phentolamine, Phenoxybenzamine, Prazosin*, Terazosin, Doxazosin, Ergotamine.
- Beta adrenergic blockers: Propanolol*, Atenolol*, Metoprolol, Nadolol, Timolol, Labetalol, Bisoprolol, Esmolol, Metoprolol, Carvedilol.
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Medicinal Chemistry 1- Unit 3
Cholinergic neurotransmitters
- Biosynthesis and metabolism of acetylcholine.
- Cholinergic receptors (Muscarinic & Nicotinic) and their distribution.
- Cholinomimetic agents: SAR of Parasympathomimetic agents
- Direct acting agents: Acetylcholine, Methacholine*, Carbachol*, Bethanechol*, Pilocarpine*, Arecoline.
- Indirect acting agents: Physostigmine*, Neostigmine*, Pyridostigmine*, Edrophonium chloride.
- Tertiary Butylnitrite, Ambemonium chloride, Isofluorophate, Echothiophate iodide, Parathione, Malathione.
- Cholinesterase reactivator: Pralidoxime chloride.
- Cholinergic Blocking agents: SAR of cholinolytic agents
- Solanaceous alkaloids and analogues: Atropine sulphate*, Hyoscine, Homatropine, Scopolamine hydrobromide, Ipratropium hydrobromide, propantheline bromide*.
- Synthetic cholinergic blocking agents: Tropicamide, Cyclopentolate, Glycopyrrolate, Clidinium bromide, Dicyclomine hydrochloride, Methantheline bromide, Oxyphenonium bromide, Isopropamide iodide, Mepenzolate bromide, Tridihexethyl chloride, Ipratropium iodide, Ethopropazine hydrochloride.
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Medicinal Chemistry 1- Unit 4
Drugs acting on Central Nervous System
- A. Sedatives and Hypnotics:
- Benzodiazepines: SAR of Benzodiazepines, Chlordiazepoxide, Diazepam*, Oxazepam, Clonazepam, Lorazepam, Alprazolam, Zopiclone.
- Barbiturates: SAR of barbiturates: Barbital*, Phenobarbital, Mephobarbital, Amobarbital, Butabarbital, Pentobarbital, Secobarbital.
- Miscellaneous:
- Amides & their cyclic derivatives: Meprobamate, Ethchlorvynol, Paraldehyde.
- B. Antipsychotics:
- Phenothiazines: SAR of Phenothiazines - Promazine hydrochloride, Chlorpromazine hydrochloride*, Triflupromazine, Thioridazine, Trifluoperazine*, Fluphenazine, Perphenazine.
- Thioxanthenes: Thiothixene.
- Butyrophenones: Haloperidol*, Droperidol, Risperidone.
- Miscellaneous: Loxapine, Molindone.
- C. Anticonvulsants: SAR of Anticonvulsants, mechanism of anticonvulsant activity
- Barbiturates: Phenobarbitone, Metharbital, Mephobarbital*
- Hydantoins: Phenytoin*, Mephenytoin, Ethotoin
- Oxazolidinediones: Trimethadione
- Succinimides: Methsuximide, Ethosuximide* Urea and monoacylureas: Phenacemide, Carbamazepine*
- Benzodiazepines: Clonazepam
- Miscellaneous: Primidone, Valproic acid, Gabapentin, Felbamate
Notes Pdf :- Click Here
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Medicinal Chemistry 1- Unit 5
Drugs acting on Central Nervous System
- General anesthetics
- Inhalation anesthetics: Halothane*, Methoxyflurane, Enflurane, Sevoflurane, Isoflurane, Desflurane.
- Ultra short acting barbiturates: Methohexital sodium*, Thiopental sodium, Thiamyl sodium.
- Dissociative anesthetics: Ketamine hydrochloride*
- Narcotic and non-narcotic analgesics
- Morphine and related drugs: SAR of Morphine analogues, Morphine sulphate, Codeine, Meperidine hydrochloride, Anileridine hydrochloride, Dihydrocodeine hydrogen phosphate, Levorphanol tartrate, Fentanyl citrate, Methadone hydrochloride, Buprenorphine hydrochloride, Pentazocine, Nalbuphine hydrochloride, Tramadol hydrochloride.
- Narcotic antagonists: Nalorphine hydrochloride, Levalorphan tartrate, Naloxone hydrochloride.
- Anti-inflammatory agents: Sodium salicylate, Aspirin, Mefenamic acid*, Meclofenamic acid, Indomethacin, Sulindac, Tolmetin, Zomepirac, Diclofenac, Ketorolac, Ibuprofen*, Naproxen, Piroxicam, Phenacetin, Acetaminophen, Antipyrine, Phenylbutazone.
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Medicinal Chemistry 1 book PDF Downloading Link
- Medicinal Chemistry I Nirali Publication Full Book PDF:- Click Here
- Medicinal Chemistry I PV Publication Full Book PDF:- Click Here
- Medicinal Chemistry I Thakur Publication Full Book PDF:- Click Here
B.Pharmacy 4th Semester Medicinal Chemistry 1 Important Question Answer:- Download PDF
B Pharmacy 4th Semester Notes
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