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Pharmaceutical Organic Chemistry 1 - Unit I
Classification, nomenclature and isomerism
Classification of Organic Compounds
Common and IUPAC systems of nomenclature of organic compounds
(up to 10 Carbons open chain and carbocyclic compounds)
Structural isomerisms in organic compounds
Pharmaceutical Organic Chemistry 1 - Unit II
Alkanes, Alkenes and Conjugated dienes***
SP³ hybridization in alkanes, Halogenation of alkanes, uses of paraffins.
Stabilities of alkenes, SP² hybridization in alkenes
E₁ and E₂ reactions – kinetics, order of reactivity of alkyl halides, rearrangement of carbocations, Sayzeff's orientation and evidences. E₁ versus E₂ reactions, Factors affecting E₁ and E₂ reactions. Ozonolysis, electrophilic addition reactions of alkenes, Markownikoff’s orientation, free radical addition reactions of alkenes, Anti Markownikoff’s orientation.
Stability of conjugated dienes, Diel-Alder, electrophilic addition, free radical addition reactions of conjugated dienes, allylic rearrangement
Pharmaceutical Organic Chemistry 1 - Unit III
Alkyl halides*
SN₁ and SN₂ reactions - kinetics, order of reactivity of alkyl halides, stereochemistry and rearrangement of carbocations.
SN₁ versus SN₂ reactions, Factors affecting SN₁ and SN₂ reactions
Structure and uses of ethylchloride, Chloroform, trichloroethylene, tetrachloroethylene, dichloromethane, tetrachloromethane and iodoform.Alcohols*
Qualitative tests, Structure and uses of Ethyl alcohol, Methyl alcohol, chlorobutanol, Cetostearyl alcohol, Benzyl alcohol, Glycerol, Propylene glycol
Pharmaceutical Organic Chemistry 1 - Unit IV
Carbonyl compounds* (Aldehydes and ketones)
Nucleophilic addition, Electromeric effect, aldol condensation, Crossed Aldol condensation, Cannizzaro reaction, Crossed Cannizzaro reaction, Benzoin condensation, Perkin condensation, qualitative tests, Structure and uses of Formaldehyde, Paraldehyde, Acetone, Chloral hydrate, Hexamine, Benzaldehyde, Vanilin, Cinnamaldehyde.
Pharmaceutical Organic Chemistry 1 - Unit V
Carboxylic acids*
Acidity of carboxylic acids, effect of substituents on acidity, inductive effect and qualitative tests for carboxylic acids, amide and ester
Structure and Uses of Acetic acid, Lactic acid, Tartaric acid, Citric acid, Succinic acid. Oxalic acid, Salicylic acid, Benzoic acid, Benzyl benzoate, Dimethyl phthalate, Methyl salicylate and Acetyl salicylic acidAliphatic amines* – Basicity, effect of substituent on Basicity. Qualitative test, Structure and uses of Ethanolamine, Ethylenediamine, Amphetamine
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B Pharmacy 2nd Semester Notes
- Human Anatomy and Physiology 2
- Pharmaceutical Organic Chemistry 1
- Pathophysiology
- Biochemistry
- Computer Applications
- Environmental Science
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